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Monday, May 18, 2020 | History

4 edition of Interferon and Its Inducers found in the catalog.

Interferon and Its Inducers

I. G. Balandin

Interferon and Its Inducers

by I. G. Balandin

  • 80 Want to read
  • 27 Currently reading

Published by Routledge .
Written in English

    Subjects:
  • Biology, Life Sciences,
  • Mathematics and Science,
  • Science,
  • Science/Mathematics,
  • Life Sciences - Biology - General,
  • Science / Biology

  • Edition Notes

    SeriesSoviet Medical Reviews Series, Section E
    The Physical Object
    FormatPaperback
    Number of Pages168
    ID Numbers
    Open LibraryOL9599927M
    ISBN 103718649217
    ISBN 109783718649211
    OCLC/WorldCa26780588

    b) Inducers of Interferons - Normal cells do not contain preformed IFN nor do they secret interferon constitutively. This is because the interferon genes are not transcribed in normal cells. Transcription of the IFN genes occurs only after exposure of cells to an appropriate inducer. Book Description. Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma).

    Interferon was first discovered in Over the last five years it has become almost a household word. Many believe it to be a drug with already proven efficacy against cancer and viral infection. The media has distorted any cool scientific view of Brand: Springer US. Nonviral Interferon Inducers THOMAS C. MERIGAN, ERIK DE CLERCQ, and GERALD H. BAUSEK From the Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California ABSTRACT Interferon production can be stimulated by a great variety of microbial and nonmicrobial agents other than viruses.

      Purchase Interferons - 1st Edition. Print Book & E-Book. ISBN , Book Edition: 1. Interferon Inducers - definition. Definition: Agents that promote the production and release of include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.


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Interferon and Its Inducers by I. G. Balandin Download PDF EPUB FB2

From book Chemotherapy of Viral Infections (pp) Interferon and Its Inducers. The purpose of this review is to describe briefly the structures of some known inducers of interferon.

The genus Flavivirus contains over 70 virus species, of which many cause disease in humans. Severe flavivirus infections are primarily characterized by encephalitic or hemorrhagic symptoms. Mortality rates vary, depending on the infecting virus species, from 1 to 2% (e.g., for the Central European encephalitis virus) up to 30 to 40% (e.g., for the Japanese encephalitis virus and the Cited by: Carter WA, Horoszewicz JS () Human interferon and its inducers: clinical program overview at Roswell Park Memorial Institute.

Cancer Treat Rep – PubMed Google Scholar Carter WA, Pitha PM, Marshall LW, Tazawa I, Tazawa S, Ts’o POP () Structural requirements of then I rC complex for induction of human by: 9.

Diseases. Interferon beta-1a and interferon beta-1b are used to treat and control multiple sclerosis, an autoimmune treatment may help in reducing attacks in relapsing-remitting multiple sclerosis and slowing disease progression and activity in secondary progressive multiple sclerosis.

Interferon therapy is used (in combination with chemotherapy and InterPro: IPR Interferon has historical significance as a possible treatment for carcinoid tumors, but its toxicity and relative lack of efficacy limit its use. In early trials, response rates ranged from 20% to 55%, with response gauged by decrease in symptom burden rather than radiographic response.

Little radiographic response has been shown with. 3 Interferon Inducers. Interferon inducers also proved to be active against flavivirus infections in animals. Poly(inosinic acid)-poly(cytidylic acid) [Poly(IC)], a synthetic double-stranded RNA and a potent inducer of IFN-α/β, delayed Modoc virus (MODV)–induced morbidity and mortality in SCID mice (Leyssen et al., ).

Several interferon inducers (Newcastle disease virus, statolon, and poly rI:poly rC) as well as exogenous mouse interferon protect mice from sporozoite-induced Plasmodium berghei malaria, as long as they are administered before the end of the preerythrocytic phase of development of the parasite.

The protective effect of the interferon inducers was related to Cited by: 4. Interferons and Interferon Inducers (Frontiers of Biology) [Finter, N. (ed).] on *FREE* shipping on qualifying offers.

Interferons and Interferon Inducers (Frontiers of Biology)Author: N. (ed). Finter. Interferons are proteins that are part of your natural defenses.

They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those : Stephanie Watson. Rent or buy Interferon And Its Inducers - Note: Supplemental materials are not guaranteed with Rental or Used book purchases. This book is an update of Interferon, published in by Dr.

Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities.

Name Interferon Inducers Accession Number DBCAT Description. Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C.

Viruses, bacteria, and protozoa have been also known to induce interferons. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response.

Interferon was named for its ability to interfere with viral proliferation. The various forms of. Zarling J.M. () Effects of Interferon and Its Inducers on Leucocytes and Their Immunologic Functions. In: Came P.E., Carter W.A. (eds) Interferons and Their Applications. Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol Cited by: 7.

The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine. It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.

Overall, interest in the medical application of interferons and inducers reached its lowest point in the. n/a Ensembl ENSG n/a UniProt P n/a RefSeq (mRNA) NM_ n/a RefSeq (protein) NP_ NP_ n/a Location (UCSC) Chr 9: – Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene.

Leukocyte interferon is produced predominantly by B Aliases: IFNA1, IFL, IFN, IFN-ALPHA, IFN-alphaD. The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes.

The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses. (Second of Three Parts) Properties of Interferon Cells from several different classes of animals, including teleost fishes, have been shown to produce Cited by: The Interferon System: an overview.

by mitogens in general. However, the crucial point is that all these inducers trigger the production of alpha interferon by macrophages and lymphocytes. the other major chapter concerning interferon action has to do with its antiproliferative hence, in some cases, with its antitumour activity.

It is. In humans, interferon caused many flu-like symptoms. Nevertheless, a subtype of interferon, interferon beta, began to be used as a therapy for multiple sclerosis in the s, and it continues to be studied by many scientists interested in its ability to act as a biological response modifier/: Ann Austin Bobbie.

The recent West Nile virus (WNV) outbreak in the United States has increased the need to identify effective therapies. Studies were conducted in cell culture and in rodent animal models to determine the efficacy of interferon-alpha (IFN-α), interferon (IFN) inducers and ribavirin, alone or in combination with IFN, in treating by: Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice Article (PDF Available) in Antimicrobial Agents and .Books on Interferon at Photon.

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Interferon and Its Inducers.